Functional Divergence of Platelet Pkc Isoforms in Thrombus Formation on Collagen*
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چکیده
FUNCTIONAL DIVERGENCE OF PLATELET PKC ISOFORMS IN THROMBUS FORMATION ON COLLAGEN* Karen Gilio, Matthew T. Harper, Judith M.E.M. Cosemans, Olga Konopatskaya, Imke C. A. Munnix, Lenneke Prinzen, Michael Leitges, Qinghang Liu, Jeffery D. Molkentin, Johan W.M. Heemskerk and Alastair W. Poole From Department of Physiology and Pharmacology, School of Medical Sciences, Bristol, United Kingdom; Department of Biochemistry, Cardiovascular Research Institute Maastricht (CARIM), University of Maastricht, Maastricht, The Netherlands; Biotechnology Centre of Oslo, University of Oslo, Oslo, Norway and Department of Molecular Cardiovascular Biology, The Children's Hospital Medical Center, Cincinnati, OH, USA. Running head: PKC isoforms in thrombus formation Address correspondence to: Johan W.M. Heemskerk, Laboratory of Cellular Thrombosis and Haemostasis, Cardiovascular Research Institute Maastricht CARIM, Department of Biochemistry, Maastricht University, P.O. Box 616, 6200 MD Maastricht (NL). Tel.: +31-43-388-1671; Fax: +31-43388-4160; E-mail [email protected] or Alastair W. Poole, Department of Physiology & Pharmacology, School of Medical Sciences, University Walk, Bristol, UK BS8 1TD. Tel.: +44-117-3311435; Fax: +44-117-331-2288; E-mail [email protected].
منابع مشابه
Functional Divergence of Platelet Protein Kinase C (PKC) Isoforms in Thrombus Formation on Collagen*
Arterial thrombosis, a major cause of myocardial infarction and stroke, is initiated by activation of blood platelets by subendothelial collagen. The protein kinase C (PKC) family centrally regulates platelet activation, and it is becoming clear that the individual PKC isoforms play distinct roles, some of which oppose each other. Here, for the first time, we address all four of the major plate...
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Platelets are highly specialized blood cells critically involved in hemostasis and thrombosis. Members of the protein kinase C (PKC) family have established roles in regulating platelet function and thrombosis, but the molecular mechanisms are not clearly understood. In particular, the conventional PKC isoform, PKC , is a major regulator of platelet granule secretion, but the molecular pathway ...
متن کاملProtein kinase C mediates platelet secretion and thrombus formation through protein kinase D2.
Platelets are highly specialized blood cells critically involved in hemostasis and thrombosis. Members of the protein kinase C (PKC) family have established roles in regulating platelet function and thrombosis, but the molecular mechanisms are not clearly understood. In particular, the conventional PKC isoform, PKCα, is a major regulator of platelet granule secretion, but the molecular pathway ...
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